张林刚:男,博士,1974年生,内蒙古大学生命科学学院 教授。
教育经历:
1993.09-1997.07 西北农林科技大学资源环境学院 环境保护 学 士
1997.09-2000.07 中科院水土保持研究所 植物逆境生理生化 硕 士
2002.07-2005.11 兰州大学生命科学学院 植物分子生物学 博 士
工作经历:
2006.03-2008.10 中科院上海植物生理生态研究所 博士后
2008.11-2009.11 中科院上海植物生理生态研究所 副研究员
2009.12-2011.11 日本学术振兴会 (JSPS) 特别研究员
2011.12-2016.03 日本冈山大学资源植物科学研究所 助教
2016.04 -2018.11 内蒙古科技大学生命科学与技术学院 教授
2018.12 -至今 内蒙古大学生命科学学院 教授
主要研究方向:
1. 光合细胞器膜系统的重建与修复
叶绿体是植物和藻类进行光合作用的细胞器,将太阳能转化为化学能并且储存在细胞内。光合功能的发挥离不来其结构的完成性,叶绿体外围的双层被膜是保护其光合功能的基本屏障。在逆境条件下(如紫外线、高温、低温和缺水条件),叶绿体被膜完整性常常受到破坏,导致膜透性增加,严重抑制光合作用和叶绿体内的其它代谢过程。我们的研究发现,VIPP1(Vesicle Inducing Protien in Plastid 1) 蛋白的主要功能是修复破损的叶绿体被膜,过表达该蛋白可以显著地增强植物的整体抗性。
2. 叶绿体生物反应器的研究与应用
叶绿体作为一种新型的生物反应器, 具有高效表达、定点整合、安全性好、表达原核性、后代遗传稳定等优点, 近几年呈现出诱人的发展前景。我们目前将 VIPP1以及一些相关蛋白在叶绿体中过量表达,以期获得生物安全性高、抗逆性强的生物新品种。
研究论文:
1.第一作者论文:
1)Ohnishi N, Zhang LG(张林刚)(并列第一作者), Sakamoto W. (2018) VIPP1 involved in chloroplast membrane integrity has GTPase activity in vitro. Plant Physiology 177: 328-338.
2)Zhang LG(张林刚), Kondo H, Kamikubo H, Kataoka M, Sakamoto W. (2016) VIPP1 has a disordered C-terminal tail necessary for protecting photosynthetic membranes against stress in Arabidopsis. Plant Physiology 171: 1983-1995.
3)Zhang LG(张林刚), Kusaba M, Tanaka A, Sakamoto W. (2016) Protection of chloroplast membranes by VIPP1 rescues aberrant seedling development in Arabidopsis nyc1 mutant. Frontiers in Plant Science. 7:533.
4)Zhang LG(张林刚), Sakamoto W. (2015) Possible Function of VIPP1 in Maintaining Chloroplast Membranes. Biochimicaet Biophysica Acta (BBA) - Bioenergetics 1847: 831-837. (Invited review).
5)Zhang LG(张林刚), Kato Y., Saigo K., Vothknecht UC, Sakamoto W. (2013) There Lattice-like Structure Observed by Vipp1-GFP in Arabidopsis chloroplasts. In Photosynthesis Research for Food, Fuel and Future. 15th International Conference on Photosynthesis. (eds. Kuang, T., Lu, C., and Zhang, L.), pp. 394-397, Springer.
6)Zhang LG(张林刚), Sakamoto W. (2013) Possible Function of VIPP1 in Thylakoids: Protection but not Formation? Plant Signaling Behavior 8: e22860.
7)Zhang LG(张林刚), Kato Y, Otters S, Vothknecht UC, Sakamoto W. (2012) Essential Role of VIPP1 in Chloroplast Envelope Maintenance in Arabidopsis. The Plant Cell 24: 3695-3707.
8)Zhang LG(张林刚), Wei Q, Wu WJ, Cheng YX, Hu GZ, Hu FH, Sun Y, Zhu Y, Skamoto W, Huang JR. (2009) Activation of the Heterotrimeric G protein α-Subunit, GPA1, Suppresses ftsh-Mediated Inhibition of Chloroplast Development in Arabidopsis. The Plant Journal 58:1041-1053.
9)Zhang LG(张林刚), Zhou S, Xuan Y, Sun M, Zhao LQ. (2009) Protective Effective of Nitric Oxide against Oxidative Damage in Arabidopsis Leaves under Ultraviolet-B Irradiation. Journal of Plant Biology 52:135-140.
10)Zhang LG(张林刚), Zhao LQ. (2008) Production of Nitric Oxide under Ultraviolet-B Irradiation Is Mediated by Hydrogen Peroxide through Activation of Nitric Oxide Synthase. Journal of Plant Biology 51:395-400.
11)Zhang LG(张林刚), Hu GZ, Cheng YX, Huang JR. (2008) Heterotrimeric G Protein α and β Subunits Antagonistically Modulate Stomatal Density in Arabidopsis thaliana. Development Biology 324:68-75.
12)Zhang LG(张林刚), Wang YD, Zhao LQ, Shi SY, Zhang LX. (2006) Involvement of Nitric Oxide in Light-mediated Greening of Barley Seedlings. Journal of Plant Physiology 163:818-826.
2.非第一作者科研论文:
1)Huang WH, Chen QB, Zhu Y, Hu FH, Zhang LG(张林刚), Ma ZH, He ZH, Huang JR. (2013) Arabidopsis Thylakoid Formation 1 Is a Critical Regulator for Dynamics of PSII-LHCII Complexes in Leaf Senescence and Excess Light. Molecular Plant 6: 1673-1691.
2)Matsushima R, Tang LY, Zhang LG(张林刚), Yamada H, Twell D, Sakamoto W. (2011) A Conserved, Mg2+-Dependent Exonuclease Degrades Organelle DNA during Arabidopsis Pollen Development. The Plant Cell 23: 1608-1624.
3)Wu WJ, Elsheery N, Wei Q, Zhang LG(张林刚), Huang JR.(2011)Defective Etioplasts Observed in Variegation Mutants May Reveal the Light-Independent Regulation of White/Yellow Sectors of Arabidopsis Leaves. Journal of Integrative Plant Biology 53: 846-857.
4)Zhang D, Kato Y, Zhang LG(张林刚), Fujimoto M, Tsutsumi N, Sodmergen, Sakamoto W. (2010) The FtsH Protease Heterocomplex in Arabidopsis: Dispensability of Type-B Protease Activity for Proper Chloroplast Development. The Plant Cell 22:3710-3725.
5)Ren GD, Zhou Q, Wu SX, Zhang YF, Zhang LG(张林刚), Huang JR, Sun ZF, Kuai BK (2010) Reverse Genetic Identification of CRN1 and Its Distinctive Role in Chlorophyll Degradation in Arabidopsis. Journal of Integrative Plant Biology 52:496-504.
6)Shi SY, Wang G, Wang YD, Zhang LG(张林刚), Zhang LX. (2005) Protective Effect of Nitric Oxide against Oxidative Stress under Ultraviolet-B Radiation. Nitric Oxide 13:1-9.
3.专著:
《叶绿体发育与保护》,张林刚著,哈尔滨工业大学出版社,2016,ISBN 978-7-5603-6374-5。
主持课题:
1.主持:国家自然基金(地区项目):两种生态型羊草不同滞绿(Stay-green)特性的机理研究 (32060400)。年限:2021.01-2024.12。(35万)(在研)
2.主持:国家自然基金(面上项目):GPA1和THF1协同调控植物气孔保卫细胞大小的机理研究(31770261)年限:2018.01-2021.12。(60万)(在研)
3.主持:国家自然基金(地区项目):VIPP1蛋白运动的调控及其修复叶绿体被膜的分子机理研究(31660062)年限:2017.01-2020.12。(41万)(结题)
荣 誉:
1.2017年入选 内蒙古“草原英才”
2.2017年入选 内蒙古自治区“新世纪321人才工程”(二层次)
3.2017年入选 内蒙古包头市“鹿城英才”